After more than sixty years we are still unclear whether LSD has a place in clinical psychiatry
Abstract
Dear Editor, The use of the psychedelic Lysergic Acid Diethylamide (LSD) has again provoked scientific debate over its efficacy and safety. In the 1950s-1960s LSD was used in psychotherapy for treating depression, anxiety related to terminal cancer, addiction, and pain. (...)
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References
Bonson, K. (1996). Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology, 14, 425-436. DOI: https://doi.org/10.1016/0893-133X(95)00145-4
Carhart-Harris, R.L., and Goodwin, G.M. (2017). The therapeutic potential of psychedelic drugs: past, present, and future. Neuropsychopharmacology 42, 2105–2113; DOI: https://doi.org/10.1038/npp.2017.84
Carhart-Harris, R.L., Bolstridge, M., & Rucker. J., et al. (2016). Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry, 3(7), 619-27. DOI: https://doi.org/10.1016/S2215-0366(16)30065-7
Fuentes, J.J., Fonseca, F., Elices, M., Farré., M., & Torrens, M. (2020) Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials. Front. Psychiatry, 10, 943.
Gasser, P., Kirchner, K., and Passie, T. (2015). LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: a qualitative study of acute and sustained subjective effects. Journal of Psychopharmacology, 29(1), 57–68. DOI: https://doi.org/10.1177/0269881114555249
Mithoefer, M.C., Wagner, T.M., Mithoefer, A.T., Jerome, L., & Doblin, R. (2011). The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439-452. DOI: https://doi.org/10.1177/0269881110378371
Mithoefer, M.C., Mithoefer, A.T., Feduccia. L., et al. (2018). MDMA-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial. Lancet Psychiatry, 55(6), 486-497. DOI: https://doi.org/10.1016/S2215-0366(18)30135-4
Nutt, D. (2019). Psychedelic drugs—a new era in psychiatry? Dialogues in Clinical Neuroscience, 21(2), 139-147. DOI: https://doi.org/10.31887/DCNS.2019.21.2/dnutt
Tupper, K.W., Wood, E., Yensen, R., & Johnson, M.W. (2015). Psychedelic medicine: a re-emerging therapeutic paradigm. CMAJ, 187(14), 1054-1059. DOI: https://doi.org/10.1503/cmaj.141124
Ungerleider, J.T., & Adrysiak, T. (1981). Therapeutic uses of the drugs of abuse. Annals of the New York Academy of Sciences, 362, 173-180. DOI: https://doi.org/10.1111/j.1749-6632.1981.tb12805.x

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